Published Research Articles
Schultz MB*, Kane AE* Mitchell SJ, MacArthur MR, Warner E, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA, Age and life expectancy clocks based on machine learning analysis of mouse frailty, Nature Communications, 2020, 11:4618, *indicates equal contribution.
Kane AE, Bisset ES, Heinze-Milne S, Keller KM, Grandy SA, Howlett SE, Maladaptive changes associated with cardiac aging are sex-specific and graded by frailty and inflammation in C57BL/6 mice, Journals of Gerontology Biological Sciences, 2020, in press.
Kane AE, Bisset ES, Keller KM, Ghimire A, Pyle WG, Howlett SE, Age, sex and overall health, measured as frailty, modify myofilament proteins in hearts from naturally aging mice, Scientific Reports, 2020, 10:10052
Mach J, Gemikonakli G, Logan C, Vander Wyk B, Allore H, Ekambareshwar S, Kane AE, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN, Chronic polypharmacy with increasing Drug Burden Index (DBI) exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. Journals of Gerontology Biological Sciences, 2020, [Epub ahead of print]
Kane AE, Keller KM, Heinze-Milne S, Grandy SA, Howlett SE, A Murine Frailty Index Based on Clinical and Laboratory Measurements: Links Between Frailty and Pro-inflammatory Cytokines Differ in a Sex-Specific Manner, Journals of Gerontology Biological Sciences, 2019, 74(3):275-282 (Editors Choice).
Keller KM*, Kane AE*, Heinze-Milne S, Grandy SA, Howlett SE, Chronic treatment with the ACE inhibitor enalapril attenuates the development of frailty and differentially modifies pro-and anti-inflammatory cytokines in aging male and female C57BL/6 mice, Journals of Gerontology Biological Sciences, 2018, 74(8):1149-1157, *indicates equal contribution.
Kane AE, Shin S, Wong AA, Fertan E, Faustova NS, Howlett SE, Brown RE, Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease, Frontiers in Aging Neuroscience, 2018, 10:172.
Feridooni HA, Kane AE, Ayaz O, Boroumandi A, Polidovitch N, Tsushima RG, Rose RA, Howlett SE. The impact of age and frailty on ventricular structure and function in C57BL/6J mice, Journal of Physiology, 2017, 12(595):3721-3742.
Kane AE, Ayaz O, Ghimire A, Feridooni H, Howlett SE. Implementation of the mouse frailty index. Canadian Journal of Physiology and Pharmacology, 2017, 95(10):1149-1155.
Kane AE, Gregson E, Theou O, Rockwood K, Howlett SE. The association between frailty, the metabolic syndrome, and mortality over the lifespan, Geroscience, 2017,39(2):221-9.
Yorke A, Kane AE, Hancock Friesen CL, Howlett SE, O’Blenes S. Development of a Rat Clinical Frailty Index, Journals of Gerontology Biological Sciences, 2017, 72(7):897-903.
Kane AE, Huizer-Pajkos A, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Howlett, SE, Hilmer SN. A Comparison of Two Mouse Frailty Assessment Tools, Journals of Gerontology Biological Sciences, 2017, 72(7):904-909.
Kane AE, Mitchell SJ, Mach J, Huizer-Pajkos A, McKenzie C, Jones B, Cogger V, Le Couteur DG, de Cabo R, Hilmer SN, Acetaminophen Hepatotoxicity in Mice: Effect of Age, Frailty and Exposure Type, Experimental Gerontology, 2016, 73:95-106.
Kane AE, Huizer-Pajkos A, Mach J, McKenzie C, Mitchell SJ, de Cabo R, Jones B, Cogger V, Le Couteur DG, Hilmer SN, N-Acetyl Cysteine does not prevent liver toxicity from chronic low dose plus sub-acute high dose paracetamol exposure in young or old mice, Fundamental and Clinical Pharmacology, 2016, 30(3):263-75.
Mach J, Huizer- Pajkos A, Mitchell SJ, McKenzie C, Phillips L, Kane AE, Jones B, de Cabo R, Cogger V, Le Couteur D, Hilmer SN, The effect of aging on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats, Fundamental and Clinical Pharmacology, 2016, 30(1):23-24.
Kane A, Hilmer SN, Boyer D, Gavin K, Nines D, Howlett S, de Cabo R, Mitchell SJ, Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index, Journals of Gerontology Biological Sciences, 2016, 71(3):333-9.
Huizer-Pajkos A, Kane AE, Howlett S, Mach J, Mitchell SJ, de Cabo R, Le Couteur D, Hilmer SN, Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging, Journals of Gerontology Biological Sciences, 2016, 71(5):571-7 (Editors Choice).
Kane AE, Hilmer SN, Huizer-Pajkos A, Mach J, Nines D, Phillips D, Gavin K, de Cabo R, Mitchell SJ, Factors That Impact On Inter-Rater Reliability of the Mouse Clinical Frailty Index, Journals of Gerontology Biological Sciences, 2015, 70 (6): 694-695.
Mach J, Huizer- Pajkos A, Kane AE, Jones B, McKenzie C, Mitchell SJ, de Cabo R, Cogger V, Le Couteur D, Hilmer SN, The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats, Experimental Gerontology, 2015, 67:54-61.
Kane A, Mitchell SJ, Carroll PR, Matthews S, Hilmer SN, Characteristics of older and younger patients with suspected paracetamol toxicity, Australasian Journal On Ageing, 2012, 31:3, 190-3.
Published Reviews and Chapters
Kane AE, Howlett SE. Spelunking the biology of frailty. Mechanisms of Ageing and Development, 2019, 182:1111123.
Kane AE, Sinclair DA. Epigenetic changes during aging and their reprogramming potential, Critical Reviews in Biochemistry and Molecular Biology, 2019, 54(1):61-83.
Kane AE, Sinclair DA. Frailty biomarkers in humans and rodents: current approaches and future advances, Mechanisms of Ageing and Development, 2019, 182:117-128.
Kane AE, Bisset ES, Howlett SE, Biology of Frailty. In: Encyclopedia of Gerontology and Population Aging, 2019, Springer.
Kane AE, Sinclair DA, Sirtuin Activators. In: Encyclopaedia of Biomedical Gerontology. 2018, Elsevier.
Kane AE, Sinclair DA, Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases, Circulation Research, 2018, 123:868–85.
Kane AE, Sinclair DA, Mitchell JR, Mitchell SJ, Sex differences in the response to dietary restriction in rodents, Current Opinion in Physiology, 2018, 6:28-34.
Kane AE, Howlett SE, Differences in Cardiovascular Aging in Men and Women, In: Sex-Specific Analysis of Cardiovascular Function, 2018, 389-411.
Kane AE, Sinclair DA, Pharmacological Approaches for Modulating Sirtuins. In: Introductory Review on Sirtuins in Biology, Aging, and Disease. 2018, Elsevier.
Ghimire A, Kane AE, Howlett SE, Sex Differences in the Physiology and Pathology of the Aging Heart. In: Encyclopedia of Cardiovascular Research and Medicine, 1st Edition. 2017, Elsevier.
Kane AE, Howlett SE, Guest Editorial: Advances in Preclinical Models of Frailty, Journals of Gerontology Biological Sciences, 2017, 72(7):867-869.
Kane A, Howlett S, Approaches to the assessment of frailty in animal models. In: Handbook of Models for Human Aging, 2nd Edition. 2017, Elsevier.
Kane AE, Hilmer SN, Mach J, Mitchell SJ, de Cabo R, Howlett SE, Animal models of frailty: Current applications in clinical research, Clinical Interventions in Ageing, 2016, 11:1519-1529.
Kane AE, Howlett SE, Novel Cardioprotective Strategies for the Aged Heart During Cardiac Surgery, Clinical and Experimental Pharmacology and Physiology, 2016, 43(12):1251-60.
Mitchell SJ, Kane AE, Hilmer SN, Age-related changes in the hepatic pharmacology and toxicology of paracetamol, Current Gerontology and Geriatrics Research, 2011.
Preprints
Lu Y, Krishnan A, Brommer B, Tian X, Meer M, Vera DL, Wang C, Zeng Q, Yu D, Bonkowski MS, Yang, J, Hoffman EM, Zhou S, Korobkina E, Davidsohn N, Schultz MB, Kane AE, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA, Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming, BioRxiv, 2019 (accepted at Nature)
Hayano M, Yang J, Bonkowski MS, Amorim JA, Ross JM, Coppotelli G, Griffin PT, Chew Y, Guo W, Yang X, Vera DL, Salfati EL, Das A, Thakur S, Kane AE, Mitchell SJ, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta A, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Oberdoerffer P, Ksander BR, Rajman LA, Sinclair DA, DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging, BioRxiv, 2019 (submitted to Cell).